Symbol
Name
ID

Fgf13
fibroblast growth factor 13
MGI:109178

Phenotype annotations related to nervous system

Darker colors indicate more annotations

Human Phenotypes

Ankle clonus

Cerebral atrophy

Babinski sign

EEG with burst suppression

Hypsarrhythmia

Delayed speech and language development

Autistic behavior

Intellectual disability

Developmental regression

Profound global developmental delay

Severe global developmental delay

Bilateral tonic-clonic seizure

Focal impaired awareness seizure

Focal-onset seizure

Disease(s) Associated with FGF13

developmental and epileptic encephalopathy 90

non-syndromic X-linked intellectual disability

Mouse Phenotypes

seizures

abnormal kindling response

environmentally induced seizures

abnormal neuron differentiation

abnormal axon extension

abnormal neuronal migration

abnormal hippocampus morphology

abnormal dentate gyrus morphology

abnormal cerebral cortex pyramidal cell morphology

abnormal stratification in cerebral cortex

abnormal cerebellar granule cell morphology

abnormal innervation

abnormal neuron morphology

abnormal axon morphology

decreased dendritic spine density

decreased neuron number

increased neuron number

abnormal CNS synaptic transmission

increased excitatory postsynaptic current frequency

abnormal inhibitory postsynaptic currents

decreased miniature inhibitory postsynaptic current amplitude

Availability

Mouse Genotype

Fgf13^tm1Jom/Fgf13⁺

Fgf13^em1Xuzh/Y

Fgf13^tm1Xuzh/Fgf13^tm1Xuzh (conditional)

Fgf13^tm1Xuzh/Fgf13^tm1Xuzh
Tg(EIIa-cre)C5379Lmgd/0 (conditional)

Fgf13^tm1Xuzh/Y
Emx1^tm1(cre)Yql/Emx1⁺ (conditional)

Fgf13^tm1Xuzh/Y
Tg(EIIa-cre)C5379Lmgd/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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